FMR1 Antilichaam

Fragile X syndrome is a frequent form of inherited mental retardation caused by functional loss of the fragile X mental retardation protein, FMR1, also known as FMRP (1) . FMR1 binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm (2) . A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome (1) . Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1) (3) .

2332

Q06787

NP_002015

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Neuroscience

FMR1 antibody is affinity chromatography purified via peptide column.

Cat. No. 1463 - Rat Brain Tissue Lysate

1 mg/mL

FMR1 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

FMR1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

FMR1 antibody is human, mouse and rat reactive. Multiple isoforms of FMR1 are known to exist.

FMR1

Cat. No. 10-301 - Human Brain Tissue Slide

Fragile X mental retardation 1

Homo sapiens

Jin P and Warren ST. Understanding the molecular basis of fragile X syndrome. Hum. Mol. Genet. 2000; 9:901-8.

Corbin F, Bouillon M, Fortin A, et al. The fragile X mental retardation protein is associated with poly (A) + mRNA in actively translating polyribosomes. Hum. Mol. Genet. 1997; 1465-72.

Lu C, Lin L, Tan H, et al. Fragile X premutation RNA is sufficient to cause primary ovarian insufficiency in mice. Hum. Mol. Genet. 2012; 5039-47.

FMR1 Antibody: Fragile X mental retardation protein 1, FMRP

ELISA, WB, IHC-P, IF

4503765

Liquid