FNDC4-eiwit, menselijk, recombinant (mFc)
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
FNDC4 acts as an anti-inflammatory factor on macrophages and improves mouse model of induced colitis. FNDC4 could suppress osteoclast formation via NF-kappaB pathway and downregulation of CXCL10. Analysis of binding of FNDC4 to different immune cell types reveals strong and specific binding to macrophages and monocytes. FNDC4 treatment of bone marrow-derived macrophages in vitro results in reduced phagocytosis, increased cell survival and reduced proinflammatory chemokine expression. Hence, treatment with FNDC4 results in a state of dampened macrophage activity, while enhancing their survival. That FNDC4 may be a factor with direct therapeutic potential in inflammatory bowel disease and possibly other inflammatory diseases.
Ice Packs
-20°C
Beschrijving
FNDC4-eiwit, menselijk, recombinant (mFc) Beschikbaar in 5 µg. Bestel eenvoudig online met snelle levering.
Specificaties
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