FNIII14

FNIII14 is derived from the 14th fibronectin (FN) type III-like (FN-III) repeat of FN molecule. FNIII14 is capable of inhibiting cell adhesion to the extracellular matrix (ECM) . FNIII14 induces a conformational change in β1-integrin from the active to the inactive form, and blocks integrin-mediated signaling. FNIII14 has anti-fibrotic, anti-cancer effect. FNIII14 can be used for research of metabolic diseases, organ fibrosis, and malignant tumors[1].

206536-96-1

12352209

Integrin

Cytoskeleton

Cancer; Metabolic Disease; Inflammation/Immunology

O=C(N[C@@H](CCC(O)=O)C(NC(C)C(N[C@@H](C(O)C)C(NC(C(C)CC)C(N[C@@H](C(O)C)C(NCC(NC(CC(C)C)C(NC(CCC(O)=O)C(N1[C@H](CCC1)C(NCC(NC(C(O)C)C(NC(CCC(O)=O)C(NC(CC2=CC=C(C=C2)O)C(NC(C(O)C)C(NC(C(C)CC)C(NC(CC3=CC=C(C=C3)O)C(NC(C(C)C)C(NC(C(C)CC)C(NC(C)C(NC(CC(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C(C(O)C)N

C103H163N21O35

2255.52

[1]Fujita, M., et al. Biofunctional Peptide FNIII14: Therapeutic Potential. Encyclopedia 2021, 1, 350-359.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P10984/

Peptides

No Development Reported