FNIP2 Antilichaam

FNIP2 Antibody: FNIP2 is the second protein found to interact with folliculin, the product of the Birt-Hogg-Dube (BHD) gene. Folliculin is thought to act as a tumor suppressor as mutations or loss of heterozygosity in this gene are associated with BHD syndrome-related renal tumors. Folliculin and FNIP1, a protein that shares 49% identity to FNIP2, bind to AMPK, an important energy sensor in cells that negatively regulates the mammalian target of rapamycin (mTOR), a protein that is thought to be the master switch for cell growth and proliferation. FNIP1 and FNIP2 are able to form homo- and heteromeric multimers, suggesting these proteins may have a functional relationship.

57600

Q9P278

NP_065891

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis

FNIP2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1467 - Rat Skeletal Muscle Tissue Lysate

1 mg/mL

FNIP2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

FNIP2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Multiple isoforms of FNIP2 are known to exist. This antibody is predicted to not cross-react with FNIP1.

FNIP2

Folliculin interacting protein 2

Homo sapiens

Hasumi H, Baba M, Hong S-B, et al. Identification and characterization of a novel folliculin-interacting protein FNIP2. Gene2008; 415:60-7.

Takagi Y, Kobayashi T, Shiono M, et al. Interaction of folliculin (Birt-Hogg-Dube gene product) with novel Fnip1-like (FnipL/Fnip2) protein. Oncogene2008; 27:5339-47.

Vocke CD, Yang Y, Pavlovich CP, et al. High frequency of somatic frameshift BHD mutations in Birt-Hogg-Dube-associated renal tumors. J. Natl. Cancer Inst.2005; 97:931-5.

Baba M, Hong SB, Sharma M, et al. Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. Proc. Natl. Acad. Sci. USA2006; 103:15552-7.

FNIP2 Antibody: FNIPL, MAPO1, FNIPL, KIAA1450, Folliculin-interacting protein 2, FNIP1-like protein

ELISA, WB, IHC-P

154689769

Liquid