Forasartan

Forasartan is an nonpeptide angiotensin AT1 receptor antagonist with an IC50 of 2.9 nM. Forasartan is also an anti-hypertension agent. Forasartan significantly inhibits preganglionic stimulation in a dose-dependent manner in vivo. Forasartan can inhibit the heart rate increase induced by angiotensin II[1][2][3].

145216-43-9

SC-52458

12352005

Angiotensin Receptor

GPCR/G Protein

Neuroscience-Neuromodulation

Cardiovascular Disease

CCCCC1=NC(CCCC)=NN1CC2=CN=C(C3=CC=CC=C3C4=NNN=N4)C=C2

C23H28N8

416.52

[1]Tokunaga, R., et al., (2001) . Possible involvement of calcium-calmodulin pathways in the positive chronotropic response to angiotensin II on the canine cardiac sympathetic ganglia. Japanese journal of pharmacology, 86 (4), 381-389.|[2]Gul, F., Parvaiz, N., & Azam, S. S. (2023) . Deciphering the relational dynamics of AF-2 domain of PAN PPAR through drug repurposing and comparative simulations. PloS one, 18 (3), e0283743.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-A0224/

Reference compound1

No Development Reported