FOS (fosfo Thr232) Antilichaam

Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.

2353

P01100

NP_005243.1

Human, Mouse

FOS (phospho Thr232) antibody was raised against a peptide sequence around phosphorylation site of threonine 232 (V-A-T (p) -P-E) derived from Human FOS .

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

48 kDa

IgG

The antibody detects endogenous levels of FOS only when phosphorylated at threonine 232.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

FOS

FBJ murine osteosarcoma viral oncogene homolog

Homo sapiens

Van Straaten F. Proc. Natl. Acad. Sci. U.S.A. 80:3183-3187 (1983) .

Hai T., Genes Dev. 3:2083-2090 (1989) .

Heilig R., Nature 421:601-607 (2003) .

FOS, G0S7, Cellular oncogene fos

WB, IHC

4885241

Liquid