Fosfo-alfa Adducine (Thr445) Polyklonale Antilichaam

Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, gamma) . Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha and beta adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha and gamma adducins are ubiquitously expressed. In contrast, beta adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca2+/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described.

Adducin phospho T445; p-Adducin phospho T445; ADD1; ADDA; Adducin 1 alpha; Adducin 1; Alpha adducin; ADDA_HUMAN.

118

P35611

Thr445

Cytoplasm, Cell membrane

Phospho-alpha Adducin (Thr445)

Unconjugated

KLH conjugated synthetic phosphopeptide derived from human alpha Adducin around the phosphorylation site of Thr445

ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)

Purified by Protein A.

1µg/µl

ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Phosphorylation

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

118

Human, Mouse, Rat