Fosfo-c-Fos (Ser362) Polyklonale Antilichaam, HRP-vervoeging

Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.

P55; AP-1; C-FOS; Proto-oncogene c-Fos; Cellular oncogene fos; G/G1 switch regulatory protein 7; FOS; GS7

2353

P01100

Ser362

Nucleus

Human, Mouse, Rat

Phospho-c-Fos (Ser362)

HRP

KLH conjugated synthetic phosphopeptide derived from human c-Fos around the phosphorylation site of Ser362

WB, ELISA, IHC-P, IHC-F

Purified by Protein A.

1µg/µl

WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500)

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Phosphorylation

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

2353

Dog, Cow, Sheep, Pig, Horse, Chicken, Rabbit