Fosfo-Dnmt3a (Ser390 + Ser393) Polyklonale Antilichaam, APC-vervoeging

Required for genome wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity.

Dnmt3a (phospho S390 + S393) ; Dnmt3a (phospho Ser390 + Ser393) ; p-Dnmt3a (phospho S390 + S393) ; DNA (cytosine 5) methyltransferase 3 alpha; DNA (cytosine 5) methyltransferase 3A; DNA (cytosine-5) -methyltransferase 3A; DNA cytosine methyltransferase 3A2; DNA methyltransferase 3a; DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA; DNM3A_HUMAN; DNMT 3a; DNMT; Dnmt3a; DNMT3A2; M.HsaIIIA; MCMT; OTTHUMP00000201149.

1788

Q9Y6K1

Ser390 + Ser393

Cytoplasm, Nucleus

Human

Phospho-Dnmt3a (Ser390 + Ser393)

APC

KLH conjugated Synthesised phosphopeptide derived from human Dnmt3a around the phosphorylation site of Ser390 + Ser393

WB, IF

Purified by Protein A.

650nm/660nm

1µg/µl

WB (WB=1:500-2000), IF (IF=1:100-500)

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Phosphorylation

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

1788