Fosfo-GATA3 (Ser308) Polyklonale Antilichaam, PE-vervoeging

Members of the GATA family share a conserved zinc finger DNA-binding domain and are capable of binding the WGATAR consensus sequence. GATA-1 is erythroid-specific and is responsible for the regulated transcription of erythroid genes. It is an essential component in the generation of the erythroid lineage. GATA-2 is expressed in embryonic brain and liver, HeLa and endothelial cells, as well as in erythroid cells. Studies with a modified GATA consensus sequence, AGATCTTA, have shown that GATA-2 and GATA-3 recognize this mutated consensus while GATA-1 has poor recognition of this sequence. This indicates broader regulatory capabilities of GATA-2 and GATA-3 than GATA-1. GATA-3 is highly expressed in T lymphocytes. GATA-4, GATA-5 and GATA-6 comprise a subfamily of transcription factors. Both GATA-4 and GATA-6 are found in heart, pancreas and ovary; lung and liver tissues exhibit GATA-6, but not GATA-4 expression. GATA-5 expression has been observed in differentiated heart and gut tissues and is present throughout the course of development in the heart. Although expression patterns of the various GATA transcription factors may overlap, it is not yet apparent how the GATA factors are able to discriminate in binding their appropriate target sites.

GATA3 phospho S308; p-GATA3 phospho S308; GATA3 phospho Ser308; p-GATA3 Ser308; GATA 3; GATA3; GATA-3; GATA binding factor 3; GATA binding protein 3; HDR; MGC2346; MGC5199; MGC5445; Trans acting T cell specic transcription factor GATA 3; GATA3_HUMAN; Trans-acting T-cell-specic transcription factor GATA-3; GATA-binding factor 3.

2625

Ser308

Nucleus

Human, Mouse

Phospho-GATA3 (Ser308)

PE

KLH conjugated synthetic phosphopeptide derived from human GATA3 around the phosphorylation site of Ser308

WB

Purified by Protein A.

496,564nm/578nm

1µg/µl

WB (1:300-5000)

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Phosphorylation

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

2625

Dog, Cow, Sheep, Rabbit, GuineaPig