Fosfo-Kir6.2 (Thr224) Polyklonale Antilichaam, PE-Cy7 Vervoeging

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM) . Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq]

P-Kir6.2 phospho T224; ATP sensitive inward rectier potassium channel 11; Beta cell inward rectier subunit; mBIR; BIR; HHF 2; HHF2; IKATP; Inward rectier K+ channel Kir6.2; Inwardly rectying potassium channel KIR6.2; IRK 11; IRK11; KCNJ11; Kir 6.2; Kir6.2; MGC133230; PHHI; Potassium channel, inwardly rectying subfamily J member 11; Potassium inwardly rectying channel J11; TNDM 3; TNDM3.

Thr224

Cell membrane

Phospho-Kir6.2 (Thr224)

PE-Cy7

KLH conjugated synthetic phosphopeptide derived from human Kir6.2 around the phosphorylation site of Thr224

WB

Purified by Protein A.

488nm/780nm

1µg/µl

WB (1:300-5000)

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Phosphorylation

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Human, Mouse, Rat, Dog, Cow, Sheep, Pig, Rabbit