Fosfo-Lck-Y505 Rabbit pAb (AMR00889N)

This gene is a member of the Src family of protein tyrosine kinases (PTKs) . The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described.

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Phospho-Lck-Y505 Rabbit pAb (AMR00889N) .

LCK; IMD22; LSK; YT16; p56lck; pp58lck

3932

P06239

Cell membrane, Cytoplasm, Cytoplasmic side, Lipid-anchor

WB 1:500 - 1:2000 IP 1:50 - 1:100

Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Calculated MW: 40kDa/58kDa/61kDa Observed MW: 56KDa

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3932

https://www.uniprot.org/uniprot/P06239

GQYQP