Fosfo-PAK3 (Ser139) Polyklonale Antilichaam, AbBy FluorTM 647 Vervoeging
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.P21-activated kinase (PAK) is actually a family of serine/threonine protein kinases, members of which are activated by small molecular weight GTPases. The three most common isoforms are PAK 1, PAK 2, and PAK 3 (also known as alpha PAK, gamma PAK, and beta PAK, respectively) . These kinases contain numerous regulatory elements that trigger diverse signaling processes such as those initiated by activated GTPases, interaction with Src homology 3 (SH3) domains, and caspase mediated proteolytic cleavage. Autophosphorylation of serine 141 (serine 144 for PAK 1 and serine 139 PAK 3), catalyzed by Cdc42, is required for activation of PAK.
PAK3_HUMAN; Beta PAK; bPAK; CDKN1A; hPAK3; Mental retardation X linked 30; MRX30; MRX47; Oligophrenin 3; OPHN3; p21 activated kinase 3; p21 CDKN1A activated kinase 3; PAK-3; PAK3 p21 protein Cdc42/Rac-activated kinase 3; PAK3beta; Pak65alpha; Pak65beta; Serine threonine protein kinase PAK 3; Stk4.
5063
Ser139
Cell membrane
• Rabbit
Phospho-PAK3 (Ser139)
• Polyclonal
• IgG
AbBy Fluor™ 647
KLH conjugated synthetic phosphopeptide derived from human PAK3 around the phosphorylation site of (Ser139)
WB, IF (IHC-P), IF (IHC-F), IF (ICC)
Purified by Protein A.
650nm/665nm
1µg/µl
WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Phosphorylation
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
5063
Human, Mouse, Rat, Dog, Cow, Horse, Rabbit
Beschrijving
Fosfo-PAK3 (Ser139) Polyklonale Antilichaam, AbBy FluorTM 647 Vervoeging Beschikbaar in 100 µL. Bestel eenvoudig online met snelle levering.
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