Fosfo-PBL Antilichaam / Fosfolambaan (Phospho-T17)

Phospholamban is a small protein found in the sarcoplasmic reticulum of cardiac muscle cells, where it plays a crucial role in regulating the calcium ion concentration and ultimately the contraction of the heart muscle. Phosphorylated phospholamban is a form of the protein that has undergone a chemical modification in which phosphate groups are added to specific amino acid residues. This modification has been found to alter the interaction of phospholamban with other proteins and enzymes in the cell, leading to changes in calcium handling and cardiac contractility. Studies have demonstrated that phosphorylated phospholamban can enhance the function of the sarcoplasmic reticulum calcium pump, which is responsible for pumping calcium ions out of the cell after each contraction. This increased activity results in improved relaxation of the heart muscle and overall cardiac function. Furthermore, research has shown that abnormalities in phosphorylated phospholamban levels are associated with various cardiac conditions, including heart failure and arrhythmias.

Western blot: 1:500-1:1000, Dot blot: 1:500

P26678

Human

The amino acids surrounding phosphorylated threonine 17 from the human protein were used as the immunogen for the Phospho-PBL antibody.

WB, DB

Antigen affinity

Antigen affinity purified

This Phospho-PBL antibody is available for research use only.

Aliquot the Phospho-PBL antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

In 1X PBS, pH 7.4, with 0.09% sodium azide

Titration of the Phospho-PBL antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Western blot testing of lysate from normal rat heart tissue and spontaneous hypertensive (SHR) rat heart tissue, using Phospho-PLB antibody.