Fosfo-PKC Epsilon (Ser729) Polyklonale Antilichaam, AbBy FluorTM 488 Vervoeging

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS) -mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008].

PKC epsilon phospho S729; PKC Epsilon phospho Ser729; p-PKC Epsilon Ser729; PKC-A; PKC alpha; AAG6; Aging associated gene 6; PICK 1; PKC A; PKCA; PKC A; PRKCA; Protein Kinase C alpha; Protein kinase C alpha type; KPCE_HUMAN.

5581

Q02156

Ser729

Cytoplasm, Nucleus, Cell membrane

Mouse

Phospho-PKC Epsilon (Ser729)

AbBy Fluor™ 488

KLH conjugated synthetic phosphopeptide derived from human PKCE around the phosphorylation site of Ser729

WB, IF (IHC-P), IF (IHC-F), IF (ICC)

Purified by Protein A.

499nm/519nm

1µg/µl

WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Phosphorylation

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

5581

Human, Rat, Dog, Cow, Sheep, Pig, Horse, Chicken, Rabbit