Fosfo-STAT3 (Tyr705) Polyklonale Antilichaam, PE-Cy7 Vervoeging

Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6) -responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity) .

APRF; HIES; ADMIO; Signal transducer and activator of transcription 3; Acute-phase response factor; STAT3

6774

P40763

Tyr705

Cytoplasm, Nucleus

Human, Mouse, Rat, Chicken

Phospho-STAT3 (Tyr705)

PE-Cy7

KLH conjugated synthetic phosphopeptide derived from human STAT3 around the phosphorylation site of Tyr705

WB, FCM

Purified by Protein A.

488nm/780nm

1µg/µl

WB (1:300-5000), FCM (1:20-100)

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Phosphorylation

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

6774