Fosfo-TSC2 Antilichaam (pT1462)

Mutations in TSC2 lead to tuberous sclerosis complex. The protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking.

Dot blot: 1:500

P49815

Human

This phospho-TSC2 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pT1462 of human TSC2.

DB, ELISA

Antigen affinity

Antigen affinity purified

This phospho-TSC2 antibody is available for research use only.

Aliquot the phospho-TSC2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

In 1X PBS, pH 7.4, with 0.09% sodium azide

Titration of the phospho-TSC2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Mouse, Rat

Dot blot analysis of phospho-TSC2 antibody. 50ng of phos-peptide or nonphos-peptide per dot were spotted.