Fosinopril-d5

Fosinopril-d5 (SQ28555-d5 (free acid) ) is deuterium labeled Fosinopril. Fosinopril (SQ28555 free acid) is the ester proagent of angiotensin-converting enzyme (ACE) inhibitor with an IC50 value of 0.18 μM. Fosinopril demonstrates a non-competitive inhibition effect on ACE activity with an Ki value of 1.675 μM[1][2].

SQ28555-d5 (free acid)

12352005

Angiotensin-converting Enzyme (ACE) ; Apoptosis; Isotope-Labeled Compounds

Apoptosis; Metabolic Enzyme/Protease; Others

Neuroscience-Neurodegeneration

Cardiovascular Disease

O=C(C([2H])([2H])C([2H])([2H])[2H])O[C@H](C(C)C)OP(CC(N1C[C@H](C2CCCCC2)C[C@H]1C(O)=O)=O)(CCCCC3=CC=CC=C3)=O

C30H41D5NO7P

568.69

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Ondetti, M.A., Structural relationships of angiotensin converting-enzyme inhibitors to pharmacologic activity. Circulation, 1988. 77 (6 Pt 2) : p. I74-8.|[3]Piepho, R.W., Overview of the angiotensin-converting-enzyme inhibitors. Am J Health Syst Pharm, 2000. 57 Suppl 1: p. S3-7.|[4]Sharma, S., et al., The hemodynamic effects of long-term ACE inhibition with fosinopril in patients with heart failure. Fosinopril Hemodynamics Study Group. Am J Ther, 1999. 6 (4) : p. 181-9.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B0690S/

Isotope-Labeled Compounds

No Development Reported