FOXP2 (NM 148899) Humaan Recombinant Proteïne

This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]

Purified recombinant protein of Human forkhead box P2 (FOXP2), transcript variant 3, full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug

CAGH44; SPCH1; TNRC10

93986

O15409, Q8N6B6, O15409-6

NM_148899

7q31.1

E. coli

N-GST and C-His

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.

Transcription Factors

97.9 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

FOXP2

Human

NP_683697

https://www.ncbi.nlm.nih.gov/gene/93986

https://www.uniprot.org/uniprot/O15409

https://www.ncbi.nlm.nih.gov/nuccore/NM_148899

https://www.ncbi.nlm.nih.gov/nuccore/NP_683697