FP802 (hydrochloride)

FP802 hydrochloride is an orally active potent TwinF interface inhibitor that disrupts and detoxifies the NMDAR/TRPM4 death complex. FP802 hydrochloride exerts powerful neuroprotective effects in the 5xFAD mouse model of Alzheimer’s disease (AD) by preventing cognitive decline, preserving neuronal structural integrity, reducing amyloid-β plaque formation, and mitigating mitochondrial pathology[1]. FP802 hydrochloride stops loss of motor neurons, reduces serum neurofilament light chain (NfL) levels, improves motor performance, and extends life in a mouse model of amyotrophic lateral sclerosis (ALS) [2]. FP802 hydrochloride can be used for AD and ALS research[1][2].

2490401-57-3

12352101

IGluR; TRP Channel

Membrane Transporter/Ion Channel; Neuronal Signaling

Neuroscience-Neurodegeneration

Neurological Disease

99.84

CCN(CC1=CC(Cl)=CC=C1)CCN.Cl.Cl

C11H19Cl3N2

285.64

[1]Yan J, et al. The NMDAR/TRPM4 death complex is a major promoter of disease progression in the 5xFAD mouse model of Alzheimer's disease. Mol Psychiatry. 2025 Aug 26.|[2]Yan J, et al. TwinF interface inhibitor FP802 stops loss of motor neurons and mitigates disease progression in a mouse model of ALS. Cell Rep Med. 2024 Feb 20;5 (2) :101413.

Room Temperature

-20°C, 3 years; 4°C, 2 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-W611371A/FP802-hydrochloride-SDS-MedChemExpress.pdf

Reference compound1

No Development Reported