FPI-1465

FPI-1465 acts a dual inhibitor of serine-β-Lactamases and Penicillin-binding proteins (PBPs) .FPI-1465 inhibits PBP2 (IC50=1.0 µg/mL) . FPI-1465 exhibits activity against β-lactamase CTX-M-15 and OXA-48 with Kds of 0.011 and 5.3 µM, respectively[1].

1452458-70-6

12352005

Bacterial; Beta-lactamase; Penicillin-binding protein (PBP)

Reference compound

Anti-infection

COVID-19-immunoregulation

Infection

https://www.medchemexpress.com/fpi-1465.html

10 mM in DMSO

O=C([C@H]1[N@@]2C(N([C@H](CC1)C2)OS(=O)(O)=O)=O)NO[C@@H]3CCNC3

C11H18N4O7S

350.35

[1]Andrew M King, et al. Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-β-Lactamases and Penicillin-Binding Proteins. ACS Chem Biol. 2016 Apr 15;11 (4) :864-8.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-139744/

Reference compound1

No Development Reported