FRL1 Antilichaam

FRL1 Antibody: The Formin-like protein 1 (FRL1) gene encodes a formin-related protein which has been implicated in morphogenesis, cyokinesis, and cell polarity. Formins are a conserved class of proteins expressed in all eukaryotes and have one DAD (diaphanous autoregulatory domain), one FH2 (formin homology 2) domain and one GBD/FH3 (Rho GTPase-binding / formin homology 3) domain. FRL1 is located in the cytoplasm and is highly expressed in the spleen, lymph node and bone marrow cells. FRL1 possibly has a role in the control of cell motility, survival of macrophages and cytoskeletal organization.

752

O95466

NP_005883

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis

FRL1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1287 - EL4 Cell Lysate

1 mg/mL

FRL1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

FRL1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

121 kDa

IgG

FRL1 antibody is human, mouse and rat reactive. Three alternatively spliced transcript variants have been observed

FMNL1

Cat. No. 17-207 - EL4 Cell Slide

Formin-like 1

Homo sapiens

Katoh M and Katoh M. Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico. Int. J. Oncol. 2003; 22:1161-8.

Yayoshi-Yamamoto S, Taniuchi I and Watanabe T. FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages. Mol. Cell. Biol. 2000; 20: 6872-81.

Favaro PM, Traina F, Vassallo J, et al. High expression of FMNL1 protein in T non-Hodgkin's lymphomas. Leuk. Res. 2006; 30:735-8.

Gomez TS, Kumar K, Medeiros RB, et al. Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse. Immunity 2007; 26:177-90.

FRL1 Antibody: FMNL, FHOD4, KW-13, C17orf1, C17orf1B, FMNL, Formin-like protein 1, CLL-associated antigen KW-13

ELISA, WB, IF

33356148

Liquid