FTL-antilichaam - middengebied: Biotine (ARP54292_P050-Biotine)

Ferritin, light polypeptide

LFTD, NBIA3

2512

P02792

NP_000137

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Sheep

The immunogen is a synthetic peptide directed towards the middle region of human FTL

FTL is the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

USHBP1; SDCBP; MYOG; KPNA3; FTL; FTH1; CEP250; CEP57; AURKA; PACSIN2; COL4A3BP; IGSF8; NAMPT; SMAD9; HTT; VKORC1; PPP1CC; POLR2D; HSPD1; HSP90AB3P; EIF4G1; TOX4; MYOC; UBC; CLEC4G; RAP2A; PIK3CA; GRB2; UCHL5; MPHOSPH6; TAF10; MPP6; IGDCC3; MAP3K12; KNG1

Biotin

Polyclonal Antibody

WB, IHC

Affinity Purified

FTL is strongly supported by BioGPS gene expression data to be expressed in HepG2

0.5 mg/ml

Cow: 79%; Dog: 93%; Guinea Pig: 92%; Horse: 86%; Human: 100%; Mouse: 100%; Pig: 93%; Rabbit: 93%; Rat: 100%; Sheep: 77%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

20kDa

Ohta, E., Neurology 70 (16 PT 2), 1493-1494 (2008)

Wet Ice

175

FTL

FTL

Rabbit

Ferritin light chain

NM_000146

ALLDLHALGSARTDPHLCDFLETHFLDEEVKLIKKMGDHLTNLHRLGGPE