FXYD7 Antilichaam

FXYD7 Antibody: FXYD7 is a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing seven invariant and six highly conserved amino acids. The FXYD proteins are tissue-specific regulators of Na, K-ATPase, with FXYD7 initially identified as a brain-specific member. FXYD7 interacts with Na, K-ATPase through its transmembrane domain and is thought to influence the affinity of Na, K-ATPase for external K+ and Na+ ions. Other members of the FXDY family have similar functions: FXYD2 regulates the properties of Na, K-ATPase, while FXYD1 (phospholemman), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems.

53822

P58549

AAH18619

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Neuroscience

FXYD7 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1302 - Human Lung Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (71%)

FXYD7 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

FXYD7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

FXYD7 antibody is human, mouse and rat reactive. FXYDY7 antibody is predicted to not react with other members of the FXDY protein family

FXYD7

FXYD domain containing ion transport regulator 7

Homo sapiens

Beguin P, Crambert G, Monnet-Tschudi F, et al. FXYD7 is a brain-specific regulator of Na, K-ATPase alpha1-beta isozymes. EMBO J. 2002; 21:3264-73

Crambert G and Geering K. FXYD proteins: new tissue-specific regulators of the ubiquitous Na, K-ATPase. Sci. STKE 2003; 2003 (166) :RE1.

Li C, Crambert G, Thuillard D, et al. role of the transmembrane domain of FXDY7 in structural and functional interactions with Na, K-ATPase. J. Biol. Chem. 2005; 280:42738-43.

FXYD7 Antibody: FXYD domain-containing ion transport regulator 7

ELISA, WB, IHC-P, IF

11612659

Liquid