FZ1-peptide

FZ1 peptide is an integrin αvβ3 agonist. FZ1 peptide binds to integrin αvβ3, effectively activates FAK, FAK-dependent AKT and ERK1/2 signaling pathways. FZ1 peptide enhances VEGFC-induced endothelial angiogenesis, accelerates diabetic skin wound healing[1].

12352209

Akt; ERK; FAK; Integrin

Cytoskeleton; MAPK/ERK Pathway; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Metabolic Disease

O=C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@H]1CC(O)=O)=O)=O)=O)=O)[C@H](CSSC[C@@H](C(O)=O)NC1=O)N

C29H49N9O12S2

779.88

[1]Wang L, et al. Cyclic Heptapeptide FZ1 Acts as an Integrin αvβ3 Agonist to Facilitate Diabetic Skin Wound Healing by Enhancing Angiogenesis. J Med Chem. 2025 Sep 25;68 (18) :19503-19520.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P11474/

Peptides

No Development Reported

ERK1; ERK2; αvβ3