FZD9 Antilichaam - N-terminaal gebied: Biotine (ARP41252 P050-Biotin)

Frizzled family receptor 9

FZD3, CD349

8326

O00144

NP_003499

Human, Mouse, Rat, Dog, Guinea Pig

The immunogen is a synthetic peptide directed towards the N terminal region of human FZD9

FZD9 contains 1 FZ (frizzled) domain and belongs to the G-protein coupled receptor Fz/Smo family. It is receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members. It may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney.

KRTAP10-3; SIAH1; MDFI; WNT7A; WNT1; WNT2

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Dog: 80%; Guinea Pig: 86%; Human: 100%; Mouse: 85%; Rat: 85%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

64kDa

Winn, R.A., (2006) J. Biol. Chem. 281 (37), 26943-26950

Wet Ice

591

FZD9

FZD9

Rabbit

Frizzled-9

NM_003508

TRNDPHALCMEAPENATAGPAEPHKGLGMLPVAPRPARPPGDLGPGAGGS