Gab2 (fosfo-Tyr643) Antilichaam

This gene is a member of the GRB2-associated binding protein (GAB) gene family and is similar to the GAB1 gene. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.

9846

Q9UQC2

NP_536739.1

Human, Mouse, Rat

Gab2 (phospho Tyr643) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 643 (V-D-Y (p) -V-Q) derived from Human Gab2 .

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

74 kDa

IgG

The antibody detects endogenous levels of Gab2 only when phosphorylated at tyrosine 643.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

GAB2

GRB2-associated binding protein 2

Homo sapiens

Nishida K., Blood 93:1809-1816 (1999) .

Nagase T., DNA Res. 5:31-39 (1998) .

Salomon A.R., Proc. Natl. Acad. Sci. U.S.A. 100:443-448 (2003) .

Pp100, GABJ, KIAA0571

WB, IHC

18105042

Liquid