GAB3 Polyklonale Antilichaam

The Gab family of adaptor proteins function as molecular scaffolds that mediate protein recrutiment to RTKs (13) . Cytokine/growth factor triggering of protein tyrosine kinase receptors (RTKs) initiates signaling cascades that progress to the nucleus where signals for activation, proliferation and differentiation occur (13) . This scaffolding mechanism represents a critical link in cytokine/growth factor signaling routes. Gab1-3 contain pleckstrin homology and potential binding sites for SH2 and SH3 domain-containing proteins (1,4,5) . The recruitment of signaling partners to Gab family members is phosphorylation dependent (1,4) . Insulin receptor and EGF-receptor signaling are among the cascades that rely on Gab family members to elicit a nuclear response to an extracellular stimulus (6,7) . The human Gab3 gene maps to chromosome Xq28 and encodes a 586 amino acid protein (5) .

Gab3; GAB3_HUMAN; GRB2-associated binder 3; GRB2-associated-binding protein 3; Growth factor receptor bound protein 2-associated protein 3.

139716

Cytoplasm, Nucleus

31-130/586

GAB3

Unconjugated

KLH conjugated synthetic peptide derived from human GAB3

WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)

Purified by Protein A.

1µg/µl

WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Unmodified

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

139716

Human, Mouse, Rat, Dog, Cow, Sheep, Pig, Horse