GABA A Receptor a3 Antilichaam

GABA (γ -aminobutyric acid) is the primary inhibitory neurotransmitter in the central nervous system and interacts with three different receptors: GABA (A), GABA (B) and GABA (C) receptor. The ionotropic GABA (A) and GABA (C) receptors are ligand-gated ion channels that produce fast inhibitory synaptic transmission. In contrast, the metabotropic GABA (B) receptor is coupled to G proteins that modulate slow inhibitory synaptic transmission (1) . Functional GABA (B) receptors form heterodimers of GABA (B) R1 and GABA (B) R2 where GABA (B) R1 binds the ligand and GABA (B) R2 is the primary G protein contact site (2) . Two isoforms of GABA (B) R1 have been cloned: GABA (B) R1a is a 130 kD protein and GABA (B) R1b is a 95 kD protein (3) . G proteins subsequently inhibit adenyl cylase activity and modulate inositol phospholipid hydrolysis. GABA (B) receptors have both pre- and postsynaptic inhibitions: presynaptic GABA (B) receptors inhibit neurotransmitter release through suppression of high threshold calcium channels, while postsynaptic GABA (B) receptors inhibit through coupled activation of inwardly rectifying potassium channels. In addition to synaptic inhibition, GABA (B) receptors may also be involved in hippocampal long-term potentiation, slow wave sleep and muscle relaxation (1) .

24947

P20236

NP_058765.1

Human, Mouse, Rat

GABA A Receptor a3 antibody was raised against a peptide sequence around aa. 33~37 (R-R-Q-E-P) derived from Rat GABA A Receptor a3.

Unconjugated

Primary Antibodies

Neuroscience

Antibodies were purified by affinity-chromatography using epitope-specific peptide

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

51 kDa

This antibody detects endogenous level of total GABA A Receptor a3 protein.

Western Blot: 1:500~1:1000

Gabra3

Gamma-aminobutyric acid (GABA) A receptor, alpha 3

This antibody was raised against a peptide sequence around aa. 33~37 (R-R-Q-E-P) derived from Rat GABA A Receptor a3.

Jones, K. A. et al. (2000) Neuropsychopharmacology 23, S41-9. Duthey, B. et al. (2002) J Biol Chem 277, 3236-41. Kaupmann, K. et al. (1997) Nature 386, 239-46.

Gabra-3, Gamma-aminobutyric acid receptor subunit alpha-3, Gabra3

WB

8393387

Liquid