GABA A Receptor beta 3 (GABRB3) (NM 000814) Humaan Recombinant Proteïne

This gene encodes a member of the ligand-gated ionic channel family. The encoded protein is one the subunits of a multi-subunit chloride channel that serves as the receptor for gamma-aminobutyric acid, a major inhibitory neurotransmitter of the mammalian nervous system. This gene is located on the long arm of chromosome 15 in a cluster with two other genes encoding related subunits of the family. This gene may be associated with the pathogenesis of several disorders including Angelman syndrome, Prader-Willi syndrome, nonsyndromic orofacial clefts, epilepsy and autism. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013]

Purified recombinant protein of Human gamma-aminobutyric acid (GABA) A receptor, beta 3 (GABRB3), transcript variant 1, Gln26-Tyr245, with N-terminal His tag, expressed in E. coli, 50ug

DEE43; ECA5; EIEE43

2562

P28472

NM_000814

15q12

E. coli

N-His

Neuroactive ligand-receptor interaction

Neuroactive ligand-receptor interaction

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

50mM Tris, 8M Urea, pH8.0.

Druggable Genome, Ion Channels: Cys-loop Receptors, Transmembrane

25.3 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

GABRB3

Human

NP_000805

https://www.ncbi.nlm.nih.gov/gene/2562

https://www.uniprot.org/uniprot/P28472

https://www.ncbi.nlm.nih.gov/nuccore/NM_000814

https://www.ncbi.nlm.nih.gov/nuccore/NP_000805