GADD45B Antilichaam - middengebied: HRP (ARP48346_P050-HRP)

Growth arrest and DNA-damage-inducible, beta

MYD118, GADD45BETA

4616

O75293

NP_056490

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig

The immunogen is a synthetic peptide directed towards the middle region of human GADD45B

The function of GADD45B is involved in the regulation of growth and apoptosis.This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

UBD; UBC; MAP3K4; GADD45GIP1; GADD45G; MAP2K7; MAP3K5; PPARG; PPARD; PCNA; PPARA; ESR1; CCNB1; CDK1; CDKN1A; GADD45A; EGR1

HRP: Horseradish Peroxidase

Polyclonal Antibody

IHC, WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

18kDa

Tornatore, L., (2008) J. Mol. Biol. 378 (1), 97-111

Wet Ice

160

GADD45B

GADD45B

Rabbit

Growth arrest and DNA damage-inducible protein GADD45 beta

NM_015675

FCCDNDINIVRVSGMQRLAQLLGEPAETQGTTEARDLHCLLVTNPHTDAW