Galbacine

Galbacin ((3S) -Zuonin A), the epimer of (-) -Zuonin A , is a AMPK activator. Galbacin can be isolated from Myristica fragrans (nutmeg). Galbacin stimulates AMPK enzyme in differentiated C2C12 cells. Galbacin also has anticancer activity, and inhibits the proliferation of lymphocyte and tumor cells. Galbacin prevents weight gain in diet-induced mice model. Galbacin can be used for metabolic syndrome (including obesity and type-2 diabetes) and caners research[1][2].

528-64-3

(3S) -Zuonin A

12352005

AMPK

Epigenetics; PI3K/Akt/mTOR

Cancer; Metabolic Disease

C[C@H]1[C@H](C)[C@@H](C2=CC=C(OCO3)C3=C2)O[C@@H]1C4=CC=C(OCO5)C5=C4

C20H20O5

340.37

[1]Nascimento M S J, et al. Effect of natural 2, 5-diaryl-3, 4-dimethyltetrahydrofuran lignans on complement activation, lymphocyte proliferation, and growth of tumor cell lines[J]. Pharmaceutical biology, 2004, 42 (6) : 449-453.|[2]Nguyen PH, et al. AMP-activated protein kinase (AMPK) activators from Myristica fragrans (nutmeg) and their anti-obesity effect. Bioorg Med Chem Lett. 2010 Jul 15;20 (14) :4128-31.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N7394/

Natural Products

No Development Reported