Galectine-1 / LGALS1-eiwit

Galectin-1 (Gal-1, GAL1), is a member of the galectins, a family of animal lectins ranging from Caenorhabditis elegans to humans, which is defined by their affinity for beta-galactosides and by significant sequence similarity in the carbohydrate-binding site. It is a homodimer with a subunit molecular mass of 14.5 kDa, which contains six cysteine residues per subunit. The cysteine residues should be in a free state to maintain a molecular structure that is capable of showing lectin activity. This endogenous lectin widely expressed at sites of inflammation and tumor growth has been postulated as an attractive immunosuppressive agent to restore immune cell tolerance and homeostasis in autoimmune and inflammatory settings. On the other hand, galectin-1 contributes to different steps of tumor progression including cell adhesion, migration, and tumor-immune escape, suggesting that blockade of galectin-1 might result in therapeutic benefits in cancer. Several potential glycoprotein ligands for galectin-1 have been identified, including lysosome-associated membrane glycoproteins and fibronectin, laminin, as well as T-cell glycoproteins CD43 and CD45. Evidence points to Gal-1 and its ligands as one of the master regulators of such immune responses as T-cell homeostasis and survival, T-cell immune disorders, inflammation, and allergies as well as host-pathogen interactions.

GAL1 Protein; GBP Protein

NP_002296.1

Human

Human

See Datasheet send with the product

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> 98 % as determined by SDS-PAGE

1.Measured by its ability to agglutinate human red blood cells. The ED50 for this effect is typically 3-30μg/mL. 2.Loaded Recombinant Human Thy1/CD90 Protein, His Tag on NTA Biosensor, can bind Recombinant Human Galectin-1 Protein with an affinity constant of 46.9 nM as determined in BLI assay (Sartorius Octet RED384) .

134

Lyophilized or frozen liquid

PBS, pH 7.4

See Datasheet

15 kDa

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

E.coli