Gallamine

Gallamine is an allosteric, selective muscarinic M2 acetylcholine receptor antagonist (EC50: 130 nM for [3H]NMS dissociation from porcine muscarinic M2 receptors) . Gallamine is also an acetylcholinesterase inhibitor (IC50s : 1070 μM, 1480 μM, 235 μM for EeAChE, hAChE, hBChE, respectively (in the absence of MeCN) ) . Gallamine increases free norepinephrine levels. Gallamine can be used as a muscle relaxant[1][2].

153-76-4

12352005

Cholinesterase (ChE) ; mAChR

GPCR/G Protein; Neuronal Signaling

Inflammation/Immunology

CCN(CC)CCOC1=C(OCCN(CC)CC)C(OCCN(CC)CC)=CC=C1

C24H45N3O3

423.63

[1]Elsinghorst PW, et al. First gallamine-tacrine hybrid: design and characterization at cholinesterases and the M2 muscarinic receptor. J Med Chem. 2007 Nov 15;50 (23) :5685-95.|[2]Matsuki A, et al. Effect of gallamine on plasma cortisol and catecholamine levels in man. Can Anaesth Soc J. 1973 Jul;20 (4) :539-45.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-180358/

Reference compound1

No Development Reported

AChE; mAChR2