Gangliotetraose

Gangliotetraose (Gg4) is a tetrasccharide, exhibits major components including GM1 and its sialylated derivatives. GM1 facilitates efflux of nuclear Ca2+ and reduces the level of nuclear Ca2+ that characterizes the differentiated neuron. GM1 affects neuronal plasticity and repair mechanisms, as well as neurotrophin release in the brain[1][2].

75645-24-8

Gg4

12352005

Others

Others

Neuroscience-Neurodegeneration

Neurological Disease

10 mM in DMSO

CC(N[C@H]([C@H]([C@H]([C@H](O1)CO)O)O[C@@H]2O[C@@H]([C@@H]([C@@H]([C@H]2O)O)O)CO)[C@@H]1O[C@H]3[C@H](O[C@H]([C@@H]([C@H]3O)O)O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O)CO)=O

C26H45NO21

707.63

[1]Okada H, et al. Complement-mediated cytolysis and azidothymidine are synergistic in HIV-1 suppression. Int Immunol. 1998 Jan;10 (1) :91-5. |[2]Ledeen RW, et al. The role of GM1 and other gangliosides in neuronal differentiation. Overview and new finding. Ann N Y Acad Sci. 1998 Jun 19;845:161-75. |[3]Zakharova IO, et al. GM1 ganglioside activates ERK1/2 and Akt downstream of Trk tyrosine kinase and protects PC12 cells against hydrogen peroxide toxicity. Neurochem Res. 2014 Nov;39 (11) :2262-75. |[4]Toffano G, et al. GM1 ganglioside stimulates the regeneration of dopaminergic neurons in the central nervous system. Brain Res. 1983 Feb 14;261 (1) :163-6.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N10512/

Natural Products

No Development Reported