GAPDH-antilichaam [2D4A7]

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is well known as one of the key enzymes involved in glycolysis. It catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD) . The enzyme exists as a tetramer of identical chains. Besides its functioning as a glycolytic enzyme in cytoplasm, recent evidence suggest that mammalian GAPDH is also involved in a great number of intracellular proceses such as membrane fusion, microtubule bundling, phosphotransferase activity, nuclear RNA export, DNA replication, and DNA repair. During the last decade a lot of findings appeared concerning the role of GAPDH in different pathologies including prostate cancer progression, programmed neuronal cell death, age- related neuronal diseases, such as Alzheimer’s and Huntington’s disease.

2597

P04406

P04406

Human

Ni-NTA purified recombinant human GAPDH expressed in E. Coli strain BL21 (DE3) .

2D4A7

Unconjugated

Primary Antibodies

Neuroscience

Batch dependent

Ascitic fluid containing 0.03% sodium azide.

None

Blue Ice

GAPDH monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG1

GAPDH

Glyceraldehyde-3-phosphate dehydrogenase

Homo sapiens

Allen R.W. J. Biol. Chem. 1987.262:649-653.

Sumner CJ. Ann Neurol 2003.54:6 47-54.

GAPD, CDABP0047, OK/SW-cl.12, Peptidyl-cysteine S-nitrosylase GAPDH, GAPDH, G3PD, GAPD, HEL-S-162eP

ELISA, WB, IHC, IF

120649