Gardenoside (Standaard)

Gardenoside is an orally active natural compound found in Gardenia fruits. Gardenoside reliefs chronic constriction injury (CCI) -induced neuropathic pain by regulating the P2X3 and P2X7 receptors. Gardenoside has an inhibitory effect on free fatty acids (FFA) -induced cellular steatosis. Gardenoside reduces reactive oxygen species (ROS) . Gardenoside can be used for anti-inflammatory, antinociceptive and hepatoprotective study[1][2][3].

24512-62-7

12352005

P2X Receptor; Reactive Oxygen Species (ROS)

Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; NF-κB

Inflammation/Immunology; Neurological Disease

O=C(C1=CO[C@@H](O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O)[C@@]3([H])[C@]1([H])C=C[C@@]3(O)CO)OC

C17H24O11

404.37

[1]Yu M, Su B, et al. Gardenoside suppresses the pain in rats model of chronic constriction injury by regulating the P2X3 and P2X7 receptors. J Recept Signal Transduct Res. 2018 Jun;38 (3) :198-203.|[2]Liang H, et al. Inhibitory Effect of Gardenoside on Free Fatty Acid-Induced Steatosis in HepG2 Hepatocytes. Int J Mol Sci. 2015 Nov 20;16 (11) :27749-56.|[3]Xia T, et al. Gardenoside ameliorates inflammation and inhibits ECM degradation in IL-1β-treated rat chondrocytes via suppressing NF-κB signaling pathways. Biochem Biophys Res Commun. 2023 Jan 15;640:164-172.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N1478R/

Reference Standards