GAS6 Antilichaam

The growth arrest-specific 6 (GAS6) protein is a gamma-carboxyglutamic acid (Gla) -containing protein and a member of a family of plasma vitamin K-dependent proteins. GAS6 is involved in vascular homeostasis, cell proliferation, apoptosis, leukocyte migration, and platelet aggregation (1,2) . GAS6 is the ligand for the type I transmembrane receptor tyrosine kinase receptors Tyro3, Axl, and Mer (3) . This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker (4) . Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia (2) .

2621

Q14393

NP_000811

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Apoptosis, Homeostasis

GAS6 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1401 - Mouse Heart Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rabbit: (95%)

GAS6 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

GAS6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

GAS6 antibody is human, mouse and rat reactive. At least four isoforms of GAS6 are known to exist; this antibody will only detect the longest isoform.

GAS6

Growth arrest-specific 6

Homo sapiens

Schneider C, King RM, and Philipson L. Genes specifically expressed at growth arrest of mammalian cells. Cell 1988; 54:787-93.

Laurance S, Lemarie CA, and Blostein MD. Growth arrest-specific gene 6 (gas6) and vascular hemostasis. Adv. Nutr. 2012; 3:196-203.

Stitt TN, Conn G, Gore M, et al. The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases. Cell 1995; 80:661-70.

Van der Meer JH, van der Poll T, and van ‘t Veer C. TAM receptors, Gas6, and protein S: roles in inflammation and hemostasis. Blood 2014; 123:2460-9.

Growth arrest-specific 6 protein, AXSF, AXLLG

ELISA, WB, IHC-P

4557617

Liquid