GBP5 Antilichaam

GBP5 Antibody: The guanylate-binding proteins (GBPs) are a family of interferon-induced GTP-binding proteins function in innate immunity against microbial and viral pathogens. In humans, there are seven GBPs from hGBP1 to hGBP7. Human GBP1 and GBP2 have been shown to exhibit antiviral activity as well as being able to regulate the inhibition of proliferation and invasion of endothelial cells in response to interferon (IFN) . GBP5 promotes selective NALP3 inflammasome responses to pathogenic bacteria and soluble but not crystalline inflammasome priming agents.

115362

Q96PP8

NP_443174

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Innate Immunity

GBP5 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1464 - Rat Liver Tissue Lysate

1 mg/mL

GBP5 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

GBP5 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

GBP5 antibody is predicted to not cross-react with other GBP family members.

GBP5

Cat. No. 10-201 - Human Liver Tissue Slide

Guanylate binding protein 5

Homo sapiens

Vestal DJ. The guanylate-binding proteins (GBPs) : proinflammatory cytokine-induced members of the dynamin superfamily with unique GTPase activity. J. Interferon Cytokine Res. 2005; 25:435-43.

Kresse A, Konermann C, Degrandi D, et al. Analyses of murine GBP homology clusters based on in silico, in vitro and in vivo studies. BMC Genomics 2008; 9:158.

Hammon M, Herrmann M, Bleiziffer O, et al. Role of guanylate binding protein-1 in vascular defects associated with chronic inflammatory diseases. J. Cell Mol. Med. 2011; 15:1582-92.

Shenoy AR, Wellington DA, Kumar P, et al. GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals. Science 2012; 336:481-5.

GBP5 Antibody: GBP-5, Guanylate-binding protein 5, GBP-TA antigen, GBP-5

ELISA, WB, IHC-P, IF

16418425

Liquid