GBP6 Antilichaam

GBP6 Antibody: The guanylate-binding proteins (GBPs), a family of interferon-induced GTP-binding proteins function in innate immunity against microbial and viral pathogens. In humans, there are seven GBPs from hGBP1 to hGBP7. Human GBP1 and GBP2 have been shown to exhibit antiviral activity as well as being able to regulate the inhibition of proliferation and invasion of endothelial cells in response to interferon (IFN) (1,3) . GBP6 is induced by IFN and hydrolyzes GTP to both GDP and GMP. The precise function of GBP6 is still under investigation.

163351

Q6ZN66

NP_940862

Human, Mouse

Unconjugated

Primary Antibodies

Innate Immunity

GBP6 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1201 - HeLa Cell Lysate

1 mg/mL

GBP6 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

GBP6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

GBP6 antibody is predicted to not cross-react with other GBP family members.

GBP6

Cat. No. 17-001 - HeLa Cell Slide

Guanylate binding protein family, member 6

Homo sapiens

Vestal DJ. The guanylate-binding proteins (GBPs) : proinflammatory cytokine-induced members of the dynamin superfamily with unique GTPase activity. J. Interferon Cytokine Res. 2005; 25:435-43.

Kresse A, Konermann C, Degrandi D, et al. Analyses of murine GBP homology clusters based on in silico, in vitro and in vivo studies. BMC Genomics 2008; 9:158.

Hammon M, Herrmann M, Bleiziffer O, et al. Role of guanylate binding protein-1 in vascular defects associated with chronic inflammatory diseases. J. Cell Mol. Med. 2011; 15:1582-92.

Olszewski MA, Gray J, and Vestal DJ. In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters. Interferon Cytokine Res. 2006; 26:328-52.

GBP6 Antibody: Guanylate-binding protein 6, GTP-binding protein 6, GBP-6

ELISA, WB, ICC, IF

157671915

Liquid