GBR-401

GBR-401 is a humanized anti-CD19 monoclonal antibody with high affinity for FcγRIIIa. GBR-401 exerts a potent in vitro and in vivo cytotoxic activity against various B-cell malignancies. GBR-401 induces cell death by antibody dependent cellular cytotoxicity (ADCC) and direct killing effect. GBR-401 demonstrates potent activity of depleting malignant B cells and prolongs mice survival in multiple xenograft severe combined immunodeficiency (SCID) mice models[1].

1931954-95-8

12352203

CD19

Immunology/Inflammation

Cancer-programmed cell death

Cancer

[1]Breton CS, et al. A novel anti-CD19 monoclonal antibody (GBR 401) with high killing activity against B cell malignancies. J Hematol Oncol. 2014 Apr 14;7:33.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P991542/

Inhibitory Antibodies

No Development Reported