GCLC Mouse Monoclonal Antibody [Kloon ID: LBI1A3]

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction. [provided by RefSeq, Oct

Carrier-free (glycerol/BSA-free) GCLC mouse monoclonal antibody, clone LBI1A3

GCL; GCS; GLCL; GLCLC

Homo sapiens glutamate-cysteine ligase catalytic subunit (GCLC), transcript variant 1, mRNA.

2729

P48506

Unconjugated

Glutathione metabolism, Metabolic pathways

Glutathione metabolism, Metabolic pathways

WB 1:200~1000, IHC 1:150

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

GCLC

https://www.ncbi.nlm.nih.gov/gene/?term=2729

https://www.uniprot.org/uniprot/P48506