GCN2-activator-1
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
GCN2 activator-1 (Compound 20) is a GCN2 activator. GCN2 activator-1 binds within the ATP-pocket of GCN2 and activates GCN2 in a GCN1-independent manner. GCN2 activator-1 activates Integrated Stress Response (ISR) in cells. GCN2 activator-1 inhibits PKR with an IC50 of 3.75 µM. GCN2 activator-1 can be used for research of pulmonary veno-occlusive disease (PVOD) [1].
315705-10-3
12352005
H302, H315, H319, H335
Eukaryotic Initiation Factor (eIF) ; Pyruvate Kinase
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Inflammation/Immunology
99.69
DMSO : 4.55 mg/mL (ultrasonic; warming; heat to 60°C)
NC1=NC(C)=C(C2=CSC(NC3=NC=CC=N3)=N2)S1
C11H10N6S2
290.37
H302, H315, H319, H335
[1]JiaYi Zhu, et al. A GCN1-independent activator of the kinase GCN2. bioRxiv 2025.06.29.662197
Blue Ice
-20°C, 3 years (Powder)
http://file.medchemexpress.com/batch_PDF/HY-W319647/GCN2-activator-1-SDS-MedChemExpress.pdf
Reference compound2
No Development Reported
EIF2
Beschrijving
GCN2 activator-1 (Compound 20) is a GCN2 activator. GCN2 activator-1 binds within the ATP-pocket of GCN2 and activates GCN2 in a GCN1-independent manner. GCN2 a
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