GCO- (GPO) 10-GCOG

GCO- (GPO) 10-GCOG is a GPO repeat-containing peptide with a single collagen triple helix structure similar to collagen. The cross-linked triple helix GCO- (GPO) 10-GCOG can form a collagen-related peptide (CRP) mimetic that tightly binds to the Yersinia adhesin YadA. YadA mediates the adhesion of the human enteric pathogen Yersinia enterocolitica to collagen and other extracellular matrix components, potentially interfering with host processes mediated by endogenous collagen-binding proteins in vivo. GCO- (GPO) 10-GCOG can be used to study YadA-associated infections[1].

12352209

Bacterial

Anti-infection

COVID-19-immunoregulation

Infection

O=C(N[C@@H](CS)C(N1[C@@H](CC(C1)O)C(NCC(N2[C@@H](CCC2)C(N3[C@@H](CC(C3)O)C(NCC(N4[C@@H](CCC4)C(N5[C@@H](CC(C5)O)C(NCC(N6[C@@H](CCC6)C(N7[C@@H](CC(C7)O)C(NCC(N8[C@@H](CCC8)C(N9[C@@H](CC(C9)O)C(NCC(N%10[C@@H](CCC%10)C(N%11[C@@H](CC(C%11)O)C(NCC(N%12[C@@H](CCC%12)C(N%13[C@@H](CC(C%13)O)C(NCC(N%14[C@@H](CCC%14)C(N%15[C@@H](CC(C%15)O)C(NCC(N%16[C@@H](CCC%16)C(N%17[C@@H](CC(C%17)O)C(NCC(N%18[C@@H](CCC%18)C(N%19[C@@H](CC(C%19)O)C(NCC(N%20[C@@H](CCC%20)C(N%21[C@@H](CC(C%21)O)C(NCC(N[C@@H](CS)C(N%22[C@@H](CC(C%22)O)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN

C142H205N37O50S2

3294.53

[1]Leo JC, et al. First analysis of a bacterial collagen-binding protein with collagen Toolkits: promiscuous binding of YadA to collagens may explain how YadA interferes with host processes. Infect Immun. 2010 Jul;78 (7) :3226-36.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P6172/

Peptides

No Development Reported