GDF-15 / GDF15 Proteïne (His Tag) (Mature Form)

Growth-differentiation factor 15 (GDF15), also known as MIC-1, is a secreted member of the transforming growth factor (TGF) -β superfamily, as a novel antihypertrophic regulatory factor in the heart. GDF-15 / GDF15 is not expressed in the normal adult heart but is induced in response to conditions that promote hypertrophy and dilated cardiomyopathy and it is expressed highly in liver. GDF-15 / GDF15 has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF-15 / GDF15 is synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein. GDF-15 / GDF15 overexpression arising from an expanded erythroid compartment contributes to iron overload in thalassemia syndromes by inhibiting hepcidin expression.

GDF-15 Protein; HG Protein; MIC-1 Protein; MIC1 Protein; NAG-1 Protein; PDF Protein; PLAB Protein; PTGFB Protein

NP_004855.2

Human

Human

His-Tag

See Datasheet send with the product

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> 90 % as determined by SDS-PAGE.

Immobilized Recombinant Human GDF-15 / GDF15 Protein (His Tag) (Mature Form) at 2 μg/mL (100 μL/well) can bind Recombinant Human GFRAL Protein (Fc Tag), the EC50 is 7.0-21.0 ng/mL.

122

Lyophilized

50mM HAc, pH 2.9.

See Datasheet

18.2 kDa (glycosylated)

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Yeast