GDF6 Antilichaam

GDF6 Antibody: Growth differentiation factors (GDFs) are members of the transforming growth factor (TGF) superfamily that is involved in embryonic development and adult tissue homeostasis. Both GDF6 and GDF7 are closely related to GDF5 which has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis. It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation. In Xenopus, GDF6 is expressed at the edge of the neural plate and within the anterior neural plate including the eye fields. GDF6 is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. It may regulate patterning of the ectoderm by interacting with bone morphogenetic proteins (BMPs), and control eye development. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), a congenital disorder of spinal segmentation.

392255

Q6KF10

NP_001001557

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction

GDF6 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1220 - SK-N-SH Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (100%)

GDF6 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

GDF6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

GDF6

Growth differentiation factor 6

Homo sapiens

Massague J. 1990. The transforming growth factor-beta family. Ann. Rev. Cell Biol.6:597-641.

McPherron AC, Lawler AM, and Lee SJ. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature1997; 387:83-90.

Hanel ML and Hensey C. Eye and neural defects associated with loss of GDF6. BMC Dev. Biol.2006; 6:43.

Settle SH Jr., Rountree RB, Sinha A, et al. Multiple joint and skeletal patterning defects caused by single and double mutations in the mouse Gdf6 and Gdf5 genes. Dev. Biol.2003; 254:116-130.

GDF6 Antibody: KFM, KFS, KFS1, KFSL, SGM1, BMP13, CDMP2, LCA17, MCOP4, SCDO4, MCOPCB6, GDF16GDF-6

ELISA, WB

48475062

Liquid