Gefitinib-gebaseerde PROTAC 3
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
2230821-27-7
C06979-5mg
EGFR
Protein Tyrosine Kinase
CC1=C (SC=N1) C2=CC=C (C=C2) CNC (=O) C3CC (CN3C (=O) C (C (C) (C) C) NC (=O) CCOCCOCCCCCOC4=C (C=C5C (=C4) C (=NC=N5) NC6=CC (=C (C=C6) F) Cl) OC) O
C47H57ClFN7O8S
Gefitinib-based PROTAC 3 which conjugates an EGFR binding element to a VHL ligand via a linker induces degradation of EGFR and mutants with DC50 of 11.7 nM and 22.3 nM in HCC827 (Exon 19 del) and H3255 (L858R) cells, respectively.
3 years -20°C powder
Beschrijving
Gefitinib-gebaseerde PROTAC 3 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
Specificaties
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