Gefrituurd 10/CD350 Polyklonale Antilichaam, APC-Cy7 Vervoeging

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Fz10; FzE7; CD350; FZ-10; hFz10; Frizzled-10; FZD10

11211

Q9ULW2

Cell membrane

Human, Mouse, Rat

101-200/581

Frizzled 10/CD350

APC-Cy7

KLH conjugated synthetic peptide derived from human Frizzled 10/CD350

WB, IF (IHC-P), IF (IHC-F), IF (ICC)

Purified by Protein A.

650nm/780nm

1µg/µl

WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Unmodified

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Due to the similarity of this protein to Frizzled 9, there is a chance that this antibody will react with this protein based on homology.

11211

Dog, Cow, Sheep, Pig, Chicken