Geiparvarin

Geiparvarin is an anticancer agent and an inhibitor of MAO-B (pIC50 = 6.84 μM) . Geiparvarin exerts anti-tumor effects by downregulating COX2 expression and inhibiting angiogenesis. Geiparvarin blocks the cell cycle at the G1 phase and induces apoptosis of cancer cells. Geiparvarin has anti-microtubule activity and destroys the cytoskeleton to exert anti-proliferative effects. Geiparvarin has research significance for lung cancer, leukemia, and breast cancer[1][2][3][4][5].

36413-91-9

12352005

Apoptosis; Caspase; COX; Microtubule/Tubulin; Monoamine Oxidase

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Immunology/Inflammation; Neuronal Signaling

Cancer

C/C(C(OC(C)1C)=CC1=O)=C\COC2=CC=C(C=CC(O3)=O)C3=C2

C19H18O5

326.34

[1]Giampietro Viola, et al. Synthesis, cytotoxicity, and apoptosis induction in human tumor cells by geiparvarin analogues. Chem Biodivers. 2004 Sep;1 (9) :1265-80.|[2]Bin Wang, et al. Geiparvarin Inhibits the Progression of Osteosarcoma by Down-regulating COX2 Expression. Chem Biodivers. 2004 Sep;1 (9) :1265-80.|[3]C Bocca, et al. Cytoskeleton-interacting activity of geiparvarin, diethylstilbestrol and conjugates. Chem Biol Interact. 2001 Sep 28;137 (3) :285-305.|[4]Angelo Carotti, et al. Natural and synthetic geiparvarins are strong and selective MAO-B inhibitors. Synthesis and SAR studies. Bioorg Med Chem Lett. 2002 Dec 16;12 (24) :3551-5.|[5]Yikai Zhang, et al. Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry. Eur J Med Chem. 2012 Jul:53:356-63.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N15657/

Natural Products

No Development Reported

Caspase 3; COX-2; MAO-B