Gemcitabine HCl
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Gemcitabine is a clinically useful anticancer agent.1 It exerts its cytotoxic effects via the metabolites gemcitabine diphosphate (dFdCDP) and gemcitabine triphosphate (dFdCTP) . dFdCTP is an inhibitor of DNA polymerase and is also incorporated in DNA strands resulting in termination of chain elongation and apoptosis. dFdCDP is an inhibitor of ribonucleotide reductase which results in depletion of deoxyribonucleotides needed for DNA synthesis. Gemcitabine metabolites have also been reported to inhibit cytidine triphosphate synthetase (CTP synthetase) 2 and deoxycytidylate deaminase (dCMP deaminase) 3. Topoisomerase 1 has also been shown to be a target for gemcitabine.4
Unconjugated
White solid
-20°C
Beschrijving
Gemcitabine HCl Beschikbaar in 10 mg. Bestel eenvoudig online met snelle levering.
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